MicroRNA-328a regulates water maze performance in PTZ-kindled rats
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- 作者：Yuhan Liaoa ; Yiqing Huanga ; Xixia Liua ; Chun Luoa ; Donghua Zoua ; Xing Weia ; Qi Huanga ; Yuan Wua ; b ; wuyuan90@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：miR-328a ; microRNA-328a ; PTZ ; pentylenetetrazole ; TLE ; temporal lobe epilepsy ; MWM ; Morris water maze ; BACE ; beta-site APP-cleaving enzyme ; APP ; amyloid precursor protein ; Abeta ; amyloid beta ; AD ; Alzheimer's disease
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：125
- 期：Complete
- 页码：205-210
- 全文大小：1216 K
文摘
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The expression of miR-328a in PTZ-kindled rats was down-regulated.
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MiR-328a could regulate the cognitive function of rats.
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The down-regulation of miR-328a might contribute to the cognitive dysfunction of PTZ kindled rats by up-regulating BACE levels.
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Part of the molecular pathway in AD might also work in epilepsy.