Anxiolytic drug, adaptol and Rg1, down-regulated inflammatory cytokines, but did not have any effect on anxiety-like behavior in mice exposed to war-field-like environment

详细信息    查看全文

• 作者：D. Kim^a ; C. Kim^a ; K. Lim^b ; Y. Heo^b ; K. Cheon^c
• 刊名：Brain, Behavior, and Immunity
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：49
• 期：supp_S
• 页码：e6-e7
• 全文大小：50 K

文摘

War field is a complicated stress environment, in which psychological stress and fatigue cumulates. The purpose of this study is to set up war field exposure stress (WS) model and to investigate restitution effects of biologically-active substances on psychoneuroimmunological regulation disturbed by WS. War-field-like environment was constructed with rotational cage to interfere sleep, metal-meshed bottom to generate electrical shock, and speaker to provide sound stress. Each experimental animal was exposed to 24 hours of stress 3 times in 2 weeks. 2 times of electric shocks and sound shocks were randomly involved in a 24-hour stress exposure. Exposure to WS increased significantly motor activity and anxiety-like behavior in mice (p<.03$p<.03$, p<.02$p<.02$, respectively). Serum corticosterone and proinflammatory cytokines, IFN纬$纬$ and TNF伪$伪$, in supernatant of T cell culture extracted from mice exposed to WS were significantly higher than that of control mice (p<.01$p<.01$, p<.001$p<.001$, p<.01$p<.01$, respectively). Anxiolytic drug, adaptol and ginsenoside Rg1, had no effect on hyper-motor activity and anxiety-like behavior of mice exposed to WS. However, adaptol and ginsenoside Rg1 down-regulated serum corticosterone level (1a2bab330e5e097" title="Click to view the MathML source">p<.04$p<.04$) and IFN纬$纬$ and TNF伪$伪$ in supernatant of T cell culture extracted from mice exposed to WS (p<.01$p<.01$, p<.02$p<.02$, respectively). This study suggests that neurobehavioral and immunological adaptation to stress may have different pathway, and adaptol and ginsenoside Rg1 may have no effects on anxiety-like behavior caused by stress.