Linolenic acid grafted hyaluronan: Process development, structural characterization, biological assessing, and stability studies
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- 作者：Gloria Huerta-Angelesa ; huerta-angeles@contipro.com" class="auth_mail" title="E-mail the corresponding author ; huertang77@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Martina Brandejsová ; a ; Jaromí ; r Kulhá ; neka ; Vojtěch Pavlí ; ka ; b ; Daniela &Scaron ; mejkalová ; a ; Hana Vá ; gnerová ; a ; Vladimí ; r Velebný ; a
- 关键词：Linolenic acid (PubChem CID ; 5280934) ; Hyaluronic acid (PubChem CID ; 24728612)
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：5 November 2016
- 年：2016
- 卷：152
- 期：Complete
- 页码：815-824
- 全文大小：1976 K
文摘
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Amphiphilic hyaluronan was prepared by linking alpha linolenic acid (ALA).
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Thermostability of linolenyl-grafted-HA was influenced by the way of drying.
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Spray drying had produced homogeneous, pure and low residual solvent HA derivatives.
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Wrong storage may change the beneficial effect of linolenic acid grafted to HA.
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The use of amphiphilic HA for encapsulation was demonstrated.