Effect of 17α-ethinyl estradiol on active phase rapid eye movement sleep microarchitecture

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• 作者：Aaron C. Pawlyk ; Peter D. Alfinito ; Darlene C. Deecher
• 关键词：Rapid eye movement sleep ; Estrogen ; Spectral ; Ovariectomy ; Active phase ; (Rodent)
• 刊名：European Journal of Pharmacology
• 出版年：2008
• 出版时间：4 September 2008
• 年：2008
• 卷：591
• 期：1-3
• 页码：315-318
• 全文大小：323 K

文摘

Estrogen treatment decreases active phase rapid eye movement (REM) sleep in ovariectomized rats. Here we explored further the effect of 17α-ethinyl estradiol (17α-EE) on active phase REM sleep in ovariectomized rats by analyzing spectral properties and the number and length of REM sleep bouts. The greatest suppression of REM sleep occurred on day 4 of 17α-EE treatment, was due to decreases in bout length, and was accompanied by decreased EEG theta power. These results further elucidate 17α-EE's effects on REM sleep and provide greater understanding of the mechanisms by which estrogens alter sleep–wakefulness patterns.