Desymmetrization of acid anhydride with asymmetric esterification catalyzed by chiral phosphoric acid
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- 作者：Ken-ichi Yamada ; &dagger ; ; yamak@tokushima-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Akinori Oonishi ; Yusuke Kuroda ; Shingo Harada ; Hiroki Kiyama ; Yousuke Yamaoka ; Kiyosei Takasu ; kay-t@pharm.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Organocatalysis ; Desymmetrization ; Acid anhydride ; Chiral phosphoric acid ; Chiral Brø ; nsted acid
- 刊名：Tetrahedron Letters
- 出版年：2016
- 出版时间：7 September 2016
- 年：2016
- 卷：57
- 期：36
- 页码：4098-4100
- 全文大小：1242 K
文摘
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Desymmetrization of acid anhydrides is powerful to obtain chiral compounds.
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Benzhydrol was the best nucleophile to realize high enantioselectivity.
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2,2-Diphenylethanol was an alternative when the reaction with benzhydrol is too slow.
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Chirality on the beta-positions was also discriminated by the chiral catalyst.