刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:22 January 2017
年:2017
卷:482
期:4
页码:1289-1295
全文大小:1535 K
卷排序:482
文摘
We report first co-crystal structures of human PTK6 with potent inhibitors bound at the ATP binding pocket. Relative difference in potency between FDA approved drug, Dasatinib and an inhibitor is delineated at the molecular level. These co-crystal structures of PTK6-KD are in DFG-in and αC-helix-out conformation.