刊名:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
出版年:2017
出版时间:February 2017
年:2017
卷:1863
期:2
页码:552-559
全文大小:1206 K
卷排序:1863
文摘
Mutant Htt promotes mitochondrial outer membrane protein MCL1 degradation via the UPS. Mutant Htt recruits VCP to the mitochondria, where VCP mediates MCL1 degradation. UBXD1 is a cofactor of VCP to facilitate MCL1 degradation in HD models.