Improving the flux distributions simulated with genome-scale metabolic models of Saccharomyces cerevisiae
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- 作者：Rui Pereiraa ; b ; Jens Nielsenb ; Isabel Rochaa ; irocha@deb.uminho.pt" class="auth_mail" title="E-mail the corresponding author
- 关键词：GEM ; genome-scale metabolic model ; pFBA ; parsimonious flux balanced analysis ; FBA ; flux balance analysis ; BPCY ; biomass product coupled yield ; PPP ; pentose phosphate pathway
- 刊名：Metabolic Engineering Communications
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：3
- 期：Complete
- 页码：153-163
- 全文大小：1901 K
文摘
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The flux distributions of the genome-scale models of Saccharomyces cerevisiae were evaluated
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Most of the tested models showed fluxes inconsistent with experimental data
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A manual curation process was performed on all reactions including NADH or NADPH
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The curated models showed flux distributions more consistent with experimental data
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Phenotype simulations improved when the curated flux distributions were used