Complaints of erectile dysfunction among men treated with a statin are not uncommon. We studied the effect of statin therapy on adrenal hormones, testosterone and erectile function. Decreased low-density lipoprotein cholesterol levels induced by statin treatment did not impact adrenal hormone levels. There was a relationship between low-density lipoprotein cholesterol on statin therapy and total/free testosterone levels. These findings will have to be confirmed in a larger number of patients.