The effects of statin treatment on adrenal and sexual function and nitric oxide levels in hypercholesterolemic male patients treated with a statin

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• 作者：Osman Baspınar ; MD^a ; Fahri Bayram ; MD^b ; Selda Korkmaz ; MD^c ; Murat Aksu ; MD^d ; Derya Kocer ; MD^e ; Oğuzhan Sıtkı Dizdar ; MD^f ; Yasin Simsek ; MD^b ; Peter P. Toth ; MD ; PhD^g ; ^h ; ^{peter.toth@cghmc.com}
• 关键词：Hypercholesterolemia ; Statin ; ACTH ; Cortisol ; Testosterone ; Erectile dysfunction ; Somatosensory evoked potential
• 刊名：Journal of Clinical Lipidology
• 出版年：2016
• 出版时间：November-December 2016
• 年：2016
• 卷：10
• 期：6
• 页码：1452-1461
• 全文大小：253 K
• 卷排序：10

文摘

Complaints of erectile dysfunction among men treated with a statin are not uncommon. We studied the effect of statin therapy on adrenal hormones, testosterone and erectile function. Decreased low-density lipoprotein cholesterol levels induced by statin treatment did not impact adrenal hormone levels. There was a relationship between low-density lipoprotein cholesterol on statin therapy and total/free testosterone levels. These findings will have to be confirmed in a larger number of patients.