Direct Observations of Amyloid 尾 Self-Assembly in Live Cells Provide Insights into Differences in the Kinetics of A尾(1-40) and A尾(1-42) Aggregation
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- 作者：Elin K. Esbjö ; rner1 ; 2 ; eline@chalmers.se" class="auth_mail ; Fiona Chan3 ; Eric Rees3 ; Miklos Erdelyi3 ; Leila M. Luheshi1 ; Carlos W. Bertoncini4 ; Clemens F. Kaminski3 ; Christopher M. Dobson1 ; Gabriele S. Kaminski Schierle3 ; gsk20@cam.ac.uk" class="auth_mail
- 刊名：Chemistry & Biology
- 出版年：19 June 2014
- 年：2014
- 卷：21
- 期：6
- 页码：732-742
- 全文大小：3951 K
文摘
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Fluorescence lifetime imaging enables observations of amyloid formation in live cells
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Cell uptake of amyloid 尾 (A尾) results in amyloid fibril formation in acidic organelles
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A尾(1–40) and A尾(1–42) peptides exhibit different aggregation kinetics in vivo
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Superresolution imaging reveals the size and shape of A尾 aggregates formed in cells