FTO is highly expressed in certain subtypes of AMLs such as MLL-rearranged AML FTO promotes leukemic oncogene-mediated cell transformation and leukemogenesis FTO targets a set of genes (e.g., ASB2 and RARA) in AML as an m6A RNA demethylase The FTO⊣ASB2/RARA axis mediates AML cell growth and (ATRA-induced) differentiation