Preparing for phase II/III HIV vaccine trials in Africa

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• 作者：Eftyhia Vardas ; Stefano Buttò ; Richard Glashoff ; Mauro S. Malnati ; Guido Poli and Mario Clerici
• 刊名：Microbes and Infection
• 出版年：2005
• 出版时间：November 2005
• 年：2005
• 卷：7
• 期：14
• 页码：1436-1444
• 全文大小：189 K

文摘

Before performing phase II/III clinical trials in Africa, preliminary studies, including assessment and building up of clinical and laboratory infrastructures, estimates of human immunodeficiency virus incidence, investigation of the background immune response, and evaluation of the cross-clade immune response, need to be done. Plans and ongoing work in the context of the AIDS Vaccine Integrated Project and some preliminary data are presented.