Monoclonal origin of primary unilateral multifocal pleomorphic adenoma of the parotid gland

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• 作者：Sylvia L. van Egmond ; MD^a ; ^{S.L.vanegmond@umcutrecht.nl} ; Wendy W.J. de Leng ; PhD^b ; Folkert H.M. Morsink ; BA^b ; G. Johan A. Offerhaus ; MD ; PhD ; MPH^b ; Lodewijk A.A. Brosens ; MD ; PhD^b ; ^{l.a.a.brosens@umcutrecht.nl}
• 关键词：Pleomorphic adenoma ; Multifocal ; Parotid gland ; Humara ; Monoclonal ; X-chromosome inactivation
• 刊名：Human Pathology
• 出版年：2013
• 出版时间：May, 2013
• 年：2013
• 卷：44
• 期：5
• 页码：923-926
• 全文大小：529 K

文摘

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Summary

Primary multiple pleomorphic adenomas in a unilateral parotid gland in previously untreated patients is a rare finding, and little is known about the etiology and pathogenesis. Here, a highly unusual case of a primary multifocal pleomorphic adenoma consisting of 15 individual nodules is presented. It is shown that all nodes are clonally related and thus share a common cell of origin excluding an independent multifocal pathogenesis. Most likely, multifocal pleomorphic adenoma represents parasitic nodules that have been detached from a main nodule, which may have been the result of undisclosed trauma.