Elimination and elemental diet therapy in eosinophilic oesophagitis

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• 作者：M.J. Warners ; MD^a ; B.J. Vlieg-Boerstra ; PhD RD^b ; A.J. Bredenoord ; MD PhD^a ; ^{a.j.bredenoord@amc.uva.nl" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Eosinophilic oesophagitis ; Dysphagia ; Food allergy ; Dietary treatment
• 刊名：Best Practice & Research Clinical Gastroenterology
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：29
• 期：5
• 页码：793-803
• 全文大小：271 K

文摘

Eosinophilic oesophagitis (EoE) is a chronic immune-mediated disorder of the oesophagus. The incidence of EoE has been raised substantially and EoE has recently become the most prevalent cause of dysphagia among the adolescents. Food and aeroallergens are believed to play a major role in the pathogenesis. Current treatment includes topical steroids and dietary therapy. Dietary therapy with elimination of causative allergens could provide a durable long-term solution. Dietary therapy in EoE consists of in elemental and empiric elimination diets. Elemental diet with amino acid-based formula is most effective in achieving disease remission but poor taste makes adherence challenging. Empiric elimination diet based on avoidance of most common food allergens offers moderate response rates, the usefulness of allergy test-directed elimination diets is questioned by low response rates. In conclusion, dietary treatments for EoE seem promising, but further refinement is required before it can become standard care.