Encapsulation of Vitamin B2 in solid lipid nanoparticles using supercritical CO₂

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• 作者：Ricardo Couto ; Victor Alvarez ; Feral Temelli ; ^{feral.temelli@ualberta.ca}
• 关键词：Fully hydrogenated canola oil ; PGSS ; Solid lipid nanoparticles ; Supercritical carbon dioxide ; Vitamin B2
• 刊名：The Journal of Supercritical Fluids
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：120
• 期：part_P2
• 页码：432-442
• 全文大小：1013 K
• 卷排序：120

文摘

A modified PGSS process with expansion into a water stream was developed. The encapsulation of Vitamin B2 in solid lipid nanoparticles was tested. Pressure, Vitamin B2 and surfactant concentrations and stabilizer MW were varied. Best conditions were 15.0 MPa, 2% Vitamin B2, 5% SLS and PEG MW of 35 kDa. Best particles had bioactive load of 0.54 mg/g and mean particle size of 104 nm.