Microfluidic assisted synthesis of silver nanoparticle-chitosan composite microparticles for antibacterial applications

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• 作者：Chih-Hui Yang^a ; Lung-Shuo Wang^b ; ^c ; Szu-Yu Chen^a ; ^b ; Mao-Chen Huang^a ; ^b ; Ya-Hua Li^a ; ^b ; Yun-Chul Lin^a ; ^b ; Pei-Fan Chen^a ; ^b ; Jei-Fu Shaw^a ; ^{shawjf@isu.edu.tw" class="auth_mail" title="E-mail the corresponding author} ; Keng-Shiang Huang^b ; ^{huangks@isu.edu.tw" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Silver ; Nanoparticles ; Chitosan ; Microfluidic ; Synthesis ; Antibacterial
• 刊名：International Journal of Pharmaceutics
• 出版年：2016
• 出版时间：30 August 2016
• 年：2016
• 卷：510
• 期：2
• 页码：493-500
• 全文大小：1858 K

文摘

Silver nanoparticle (Ag NP)-loaded chitosan composites have numerous biomedical applications; however, fabricating uniform composite microparticles remains challenging. This paper presents a novel microfluidic approach for single-step and in situ synthesis of Ag NP-loaded chitosan microparticles. This proposed approach enables obtaining uniform and monodisperse Ag NP-loaded chitosan microparticles measuring several hundred micrometers. In addition, the diameter of the composites can be tuned by adjusting the flow on the microfluidic chip. The composite particles containing Ag NPs were characterized using UV–vis spectra and scanning electron microscopy-energy dispersive X-ray spectrometry data. The characteristic peaks of Ag NPs in the UV–vis spectra and the element mapping or pattern revealed the formation of nanosized silver particles. The results of antibacterial tests indicated that both chitosan and composite particles showed antibacterial ability, and Ag NPs could enhance the inhibition rate and exhibited dose-dependent antibacterial ability. Because of the properties of Ag NPs and chitosan, the synthesized composite microparticles can be used in several future potential applications, such as bactericidal agents for water disinfection, antipathogens, and surface plasma resonance enhancers.