文摘
FANCB, FANCL, and FAAP100 form a symmetric dimer of trimers FANCL is ideally poised for the symmetric mono-ubiquitination of FANCI-FANCD2 Two separate FANCC-FANCE-FANCF complexes bind to the opposing poles of FANCB-FANCL-FAAP100 FANCC-FANCE-FANCF stabilizes FANCI-FANCD2 for efficient mono-ubiquitination