刊名:Biochimica et Biophysica Acta (BBA) - Biomembranes
出版年:2017
出版时间:February 2017
年:2017
卷:1859
期:2
页码:228-237
全文大小:762 K
卷排序:1859
文摘
PGLa-H is one of the smallest natural antimicrobial peptides but is poorly active. Doubling its size in a tandem repeat enhanced peptide activity. A rationally guided point mutation (Val15 → Gly) improved peptide selectivity. Cytotoxicity and genotoxicity towards host blood cells were low for both peptides. Peptides were bactericidal for multidrug resistant clinical isolates.