Intravenous infusion of mesenchymal stem cells promotes functional recovery in a model of chronic spinal cord injury
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- 作者：Tomonori Moritaa ; b ; Masanori Sasakia ; c ; d ; msasaki@sapmed.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yuko Kataoka-Sasakia ; Masahito Nakazakia ; Hiroshi Nagahamaa ; Shinichi Okaa ; Tsutomu Oshigiria ; b ; Tsuneo Takebayashib ; Toshihiko Yamashitab ; Jeffery D. Kocsisc ; d ; Osamu Honmoua ; c ; d
- 关键词：BBB ; Basso ; Beattie ; and Bresnahan ; BSCB ; blood spinal cord barrier ; CST ; corticospinal tract ; DMEM ; Dulbecco&rsquo ; s modified Eagle&rsquo ; s medium ; EDTA ; ethylenediaminetetraacetic acid ; EvB ; Evans Blue ; MSCs ; mesenchymal stem cells ; NDS ; normal donkey serum ; PBS ; phosphate-buffered saline ; SCI ; spinal cord injury ; TCA ; trichloroacetic acid
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：29 October 2016
- 年：2016
- 卷：335
- 期：Complete
- 页码：221-231
- 全文大小：2376 K
文摘
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IV infusion of MSCs in the chronic phase of SCI improved locomotor function.
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Some infused MSCs distributed to the injured spinal cord.
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IV MSC infusion rapidly reduced intravenous dye leakage into the injured spinal cord.
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RECA-1 and PDGFR β positive microvasculature was more prevalent in the MSC-group.
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MSC-group showed greater anatomical repair in the chronic SCI.