Asthma in the elderly: Current understanding and future research needs¡ªa report of a National Institute on Aging (NIA) workshop

详细信息    查看全文

• 作者：Nicola A.  ; Hanania MD ; MS ; (Co-chair)^a ;   ; ^&lowast ; ; Monroe J.  ; King DO ; (Chair)^b ;   ; ^&lowast ; ;   ; ^{m.james.king@me.com} ; Sidney S.  ; Braman MD^c ; Carol  ; Saltoun MD^d ; Robert A.  ; Wise MD^e ; Paul  ; Enright MD^f ; Ann R.  ; Falsey MD^g ; Sameer K.  ; Mathur MD ; PhD^h ; Joe W.  ; Ramsdell MDⁱ ; Linda  ; Rogers MD^j ; David A.  ; Stempel MD^k ; John J.  ; Lima PharmD^l ; James E.  ; Fish MD^m ; Sandra R.  ; Wilson PhDⁿ ; Cynthia  ; Boyd MD ; MPH^e ; Kushang V.  ; Patel PhD^o ; Charles G.  ; Irvin PhD^p ; Barbara P.  ; Yawn MD ; MSc^q ; Ethan A.  ; Halm MD ; MPH^r ; Stephen I.  ; Wasserman MDⁱ ; Mark F.  ; Sands MD^s ; William B.  ; Ershler MD^t ; Dennis K.  ; Ledford MD^b ; Asthma in the Elderly workshop participants
• 关键词：Aging ; airway ; allergy ; asthma ; elderly ; immune mechanisms ; immunosenescence
• 刊名：Journal of Allergy and Clinical Immunology
• 出版年：2011
• 出版时间：September 2011
• 年：2011
• 卷：128
• 期：3_supp_S
• 页码：S4-S24
• 全文大小：269 K

文摘

Asthma in the elderly is underdiagnosed and undertreated, and there is a paucity of knowledge on the subject. The National Institute on Aging convened this workshop to identify what is known and what gaps in knowledge remain and suggest research directions needed to improve the understanding and care of asthma in the elderly. Asthma presenting at an advanced age often has similar clinical and physiologic consequences as seen with younger patients, but comorbid illnesses and the psychosocial effects of aging might affect the diagnosis, clinical presentation, and care of asthma in this population. At least 2 phenotypes exist among elderly patients with asthma; those with longstanding asthma have more severe airflow limitation and less complete reversibility than those with late-onset asthma. Many challenges exist in the recognition and treatment of asthma in the elderly. Furthermore, the pathophysiologic mechanisms of asthma in the elderly are likely to be different from those seen in young asthmatic patients, and these differences might influence the clinical course and outcomes of asthma in this population.