Potential role of 8-oxoguanine DNA glycosylase 1 as a STAT1 coactivator in endotoxin-induced inflammatory response
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- 作者：Hong Sook Kima ; 1 ; Byung-Hak Kima ; b ; 1 ; Joo Eun Junga ; c ; Chang Seok Leea ; d ; Hyun Gyu Leee ; Jung Weon Leef ; g ; Kun Ho Leeh ; Ho Jin Youi ; Myung-Hee Chunga ; j ; Sang-Kyu Yea ; b ; k ; l ; sangkyu@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：BER ; base excision repair ; ChIP ; chromatin immunoprecipitation ; COX-2 ; cyclooxygenase-2 ; EAE ; experimental autoimmune encephalomyelitis ; faPyG ; 2 ; 6-diamino-4-hydroxy-5-formamidopyrimidine ; GAS ; gamma-interferon activation site ; iNOS ; inducible nitric oxide synthase ; LPS ; lipopolysaccharide ; MOG ; myelin oligodendrocyte glycoprotein ; OGG1 ; 8-oxoguanine DNA glycosylase ; 8-oxoG ; 8-hydroxyguanine ; OVA ; ovalbumin ; ROS ; reactive oxygen species ; STAT1 ; signal transducer and activator of transcription 1
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：93
- 期：Complete
- 页码：12-22
- 全文大小：2231 K
文摘
- 5">
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5">OGG1 expression is increased in inflammatory conditions.
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OGG1 regulates the transcription of pro-inflammatory mediators.
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5">STAT1 regulates endotoxin-induced OGG1 expression.
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OGG1 directly interacts with STAT1 and acts as a STAT1 coactivator.
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5">OGG1 has transcriptional activity by itself.