Asymmetry-Defective Oligodendrocyte Progenitors Are Glioma Precursors

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• 作者：Sista Sugiarto¹ ; Anders  ; I. Persson² ;   ; ¹² ; Elena  ; Gonzalez Munoz¹ ;   ; ¹² ;   ; ¹³ ; Markus Waldhuber¹ ;   ; ⁸ ;   ; ¹² ; Chrystelle Lamagna¹ ;   ; ³ ; Noemi Andor¹ ; Patrizia Hanecker¹ ; Jennifer Ayers-Ringler¹ ; Joanna Phillips¹ ;   ; ⁴ ; Jason Siu⁶ ; Daniel A. Lim¹ ;   ; ⁶ ; Scott Vandenberg⁹ ; William Stallcup¹⁰ ; Mitchel  ; S. Berger¹ ;   ; ⁷ ;   ; ¹¹ ; Gabriele Bergers¹ ;   ; ⁵ ;   ; ⁷ ;   ; ¹¹ ; William  ; A. Weiss¹ ;   ; ² ;   ; ⁷ ;   ; ¹¹ ; Claudia Petritsch¹ ;   ; ⁶ ;   ; ⁷ ;   ; ¹¹ ;   ; ^{Claudia.petritsch@ucsf.edu}
• 刊名：Cancer Cell
• 出版年：2011
• 出版时间：13 September 2011
• 年：2011
• 卷：20
• 期：3
• 页码：328-340
• 全文大小：2107 K

文摘

Summary

Postnatal oligodendrocyte progenitor cells (OPC) self-renew, generate mature oligodendrocytes, and are?a cellular origin of oligodendrogliomas. We show that the proteoglycan NG2 segregates asymmetrically during mitosis to generate OPC cells of distinct fate. NG2 is required for asymmetric segregation of EGFR to the NG2⁺ progeny, which consequently activates EGFR and undergoes EGF-dependent proliferation and self-renewal. In contrast, the NG2^{?/sup> progeny differentiates. In a mouse model, decreased NG2 asymmetry coincides with premalignant, abnormal self-renewal rather than differentiation and with tumor-initiating potential. Asymmetric division of human NG2+ cells is prevalent in non-neoplastic tissue but is decreased in oligodendrogliomas. Regulators of asymmetric cell division are misexpressed in low-grade oligodendrogliomas. Our results identify loss of asymmetric division associated with the neoplastic transformation of OPC.}