Unexpected distribution of CA19.9 and other type 1 chain Lewis antigens in normal and cancer tissues of colon and pancreas: Importance of the detection method and role of glycosyltransferase regulation
刊名:Biochimica et Biophysica Acta (BBA) - General Subjects
出版年:2017
出版时间:January 2017
年:2017
卷:1861
期:1
页码:3210-3220
全文大小:3084 K
卷排序:1861
文摘
Immunofluorescence is recommended for detecting CA19.9 on tissue sections. Ratio between ST3GAL3 and B3GALT5 transcripts affects tissue expression of CA19.9. Cancer associated patterns of Lewis antigens are different in colon and pancreas. Tissue specific DNA methylation regulates B3GALT5 affecting Lewis antigen expression.