Evaluation of heat hyperalgesia and anxiety like-behaviors in a rat model of orofacial cancer
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- 作者：Eder Gambeta ; Caroline Machado Kopruszinski ; Renata Cristiane dos Reis ; Janaina Menezes Zanoveli ; janaina.zanoveli@ufpr.br" class="auth_mail" title="E-mail the corresponding author ; janainamz@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Juliana Geremias Chichorro
- 关键词：Hyperalgesia ; Anxiety ; Cancer ; Lidocaine ; Midazolam ; Rats
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：21 April 2016
- 年：2016
- 卷：619
- 期：Complete
- 页码：100-105
- 全文大小：776 K
文摘
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Rats with orofacial cancer developed heat hyperalgesia.
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Anxiety-like behavior was observed in rats with orofacial cancer.
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Lidocaine showed a transient anti-hyperalgesic effect, but did not affect anxiety-like behaviors.
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Midazolam reduced the anxiety-like behaviors, but did not modify heat hyperalgesia.