Different pattern of association of paraoxonase Gln192→Arg polymorphism with sporadic late-onset Alzheimer's disease and coronary artery disease

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• 作者：Scacchi ; Renato ; Gambina ; Giuseppe ; Martini ; Maria Cristina ; Broggio ; Elisabetta ; Vilardo ; Teresio ; et. al.
• 关键词：Alzheimer's disease ; Coronary artery disease ; DNA polymorphisms ; Paraoxonase
• 刊名：Neuroscience Letters
• 出版年：2003
• 出版时间：March 13, 2003
• 年：2003
• 卷：339
• 期：1
• 页码：17-20
• 全文大小：77.1 K

文摘

The paraoxonase (PON1) Gln192→Arg polymorphism was examined in a group of sporadic late-onset Alzheimer's disease (AD) patients, in a group of coronary artery disease (CAD) patients, and in normal subjects. The AD sample showed a PON1*R allele frequency significantly lower than the control group (0.225 vs. 0.281, P=0.049). In the CAD patients the *R allele was more frequent than in the controls (0.230 vs. 0.213), though not significantly (P=0.28). The odds ratios (OR) adjusted for age, gender, and APOE polymorphism by logistic regression analysis highlighted that in AD the PON1 RR genotype was significantly protective (OR=0.41, 95 % CI=0.19–0.90; P=0.025), whereas in CAD it appeared to be a significant risk factor (OR=5.11, 95 % CI=1.09–23.9; P=0.038) limited to younger patients.