Different photodegradation behavior of barnidipine under natural and forced irradiation
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- 作者：Giuseppina Ioele ; Filomena Oliverio ; Inmaculada Andreu ; Michele De Luca ; Miguel A. Mir ; a ; Gaetano Ragno
- 关键词：Barnidipine ; Photodegradation ; Derivative spectrophotometry ; HPLC ; ICH degradation test
- 刊名：Journal of Photochemistry and Photobiology A: Chemistry
- 出版年：2010
- 出版时间：25 September 2010
- 年：2010
- 卷：215
- 期：2-3
- 页码：205-213
- 全文大小：734 K
文摘
An in depth study on photodegradation of barnidipine, a new 1,4-dihydropyridine antihypertensive drug, was performed by exposing the drug to natural and stressing light irradiation. A different degradation process and distribution of photoproducts under different light sources and irradiation power were demonstrated. Degradation kinetics, reactive excited states involved, transient species and photoproducts generated were investigated. Exposure of barnidipine to forced irradiation caused a complex degradation pathway. Kinetics of this process was studied by HPLC and spectrophotometry, demonstrating the formation of several by-products. In contrast, the drug, under direct or indirect sunlight, underwent oxidation generating the pyridine derivative as the main photodegradation product, according to most of the drug congeners. HPLC and derivative spectrophotometric methods were defined for the simultaneous assay of the drug and its pyridinic by-product, useful as a routine control method of the drug formulations.