MSRV envelope protein is a potent, endogenous and pathogenic agonist of human toll-like receptor 4: Relevance of GNbAC1 in multiple sclerosis treatment
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- 作者：Alexandra Madeiraa ; Ingrid Burgelinb ; Hervé ; Perrona ; b ; Francois Curtinb ; Alois B. Langb ; Raphael Faucarda ; rf@geneuro.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CNS ; central nervous system ; CSF ; cerebrospinal fluid ; DAMP ; danger-associated molecular pattern ; EAE ; experimental allergic encephalomyelitis ; ELISA ; enzyme-linked immunosorbent assay ; HERV ; human endogenous retrovirus ; hOPC ; human oligodendrocytes precursors cells ; hPBMC ; human peripheral blood mononuclear cells ; hTLR4 ; human toll-like receptor 4 ; Ig ; Immunoglobulin ; IL-6 ; interleukine 6 ; LPS ; lipopolysaccharide ; MS ; multiple sclerosis ; MSRV ; multiple sclerosis associated retrovirus ; MSRV-Env
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：291
- 期：Complete
- 页码：29-38
- 全文大小：1288 K
文摘
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MSRV-Env is a full and highly potent agonist of human TLR4.
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MSRV-Env has strong pro-inflammatory properties in vitro and in vivo.
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MSRV-Env impairs human OPC maturation to myelinating oligodendrocytes.
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GNbAC1 inhibits MSRV-Env in all models investigated.
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GNbAC1 may offer a new therapeutic option for MS treatment.