Role of glutathione S-transferase P-1 (GSTP-1) gene polymorphism in COPD patients

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• 作者：Tarek F. El-Gazzar^a ; ^{drtarekelgazzar@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Samy S. El-dahdouh^b ; Ibrahim I. El-Mahalawy^b ; Hisham E. Abd El-aty^b ; Safaa I. Tayel^c
• 关键词：COPD ; GSTP1 gene polymorphism
• 刊名：Egyptian Journal of Chest Diseases and Tuberculosis
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：65
• 期：4
• 页码：739-744
• 全文大小：539 K

文摘

COPD is a multifactorial disease. It is a widely distributed disease with high morbidity and mortality, associated with different pathologies. The link between glutathione S-transferase P-1 (GSTP1) polymorphism and COPD needs to be clarified.

Objectives

To show the relationship between GSTP1 gene polymorphism and pathogenesis of COPD, and to clarify the role of smoking in GSTP1 gene polymorphism.

Patients and methods

This study carried out on 30 COPD patients met the clinical criteria of COPD set by GOLD 2013 and 20 healthy controls. Blood was sampled for studying GSTP1 gene polymorphism by PCR-RFLP.

Results

There was a significant difference between group A (COPD smokers) and group B (COPD non smokers) regarding the presence of non mutant and heterozygous mutation. GSTP1 mutation was significantly higher in group C (smoking controls) than group D (non smoking controls). There was a highly significant difference between smoking subjects than non smoking compared with mutation. There was no significant difference in mutation between smokers and ex-smokers. There was no significant difference between studied subjects having heterozygous mutation and subjects without as regards their spirometry results.

Conclusion

There is a significant association between GSTP1 gene polymorphism and the development of COPD, and smoking have a role in GSTP1 gene polymorphism. The polymorphism has no relation to disease severity.