文摘
Four new sesqui-lignans, (7R, 7'R, 7″S, 8S, 8′S, 8″S)-4′,5″-dihydroxy-3,5,3′,4″-tetramethoxy-7,9′:7′,9-diepoxy-4,8″-oxy-8,8′-sesquineo-lignan-7″,9″-diol (boldFont">1), (7R, 7'R, 7″S, 8S, 8′S, 8″S)-4′,3″-dihydroxy-3,5,3′,5′,4″-pentamethoxy-7,9′:7′,9-diepoxy-4,8″-oxy-8,8′-sesquineo-lignan-7″,9″-diol (boldFont">2), (7R, 7'R, 7″S, 8S, 8′S, 8″S)-3′,4″-dihydroxy-3,5,4′,5″-tetramethoxy-7,9′:7′,9-diepoxy-4,8″-oxy-8,8′-sesquineo-lignan-7″,9″-diol (boldFont">3) and acanthopanax A (boldFont">7) together with three known compounds (boldFont">4–boldFont">6) were isolated from the EtOAc-soluble extract of Acanthopanax senticosus. Their structures were elucidated on the basis of spectroscopic and physicochemical analyses. All the isolates were evaluated for in vitro inhibitory activity against DGAT1 and DGAT2. Among them, compounds boldFont">1–boldFont">6 were found to exhibit selective inhibitory activity on DGAT1 with IC50 values ranging from 61.1 ± 1.3 to 97.7 ± 1.1 μM and compound boldFont">7 showed selective inhibition of DGAT2 with IC50 value 93.2 ± 1.2.