Four new sesqui-lignans isolated from Acanthopanax senticosus and their diacylglycerol acyltransferase (DGAT) inhibitory activity

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• 作者：Jia-Lin Li^a ; ¹ ; Na Li^a ; ¹ ; Hyun-Sun Lee^b ; Shan-Shan Xing^a ; Shi-Zhou Qi^a ; Zhen-Dong Tuo^a ; Le Zhang^a ; Ban-Ban Li^a ; Jian-Guang Chen^a ; Long Cui^a ; ^{cuilong71@beihua.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Acanthopanax senticosus ; DGAT ; Sesqui-lignans
• 刊名：Fitoterapia
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：109
• 期：Complete
• 页码：185-189
• 全文大小：370 K

文摘

Four new sesqui-lignans, (7R, 7'R, 7″S, 8S, 8′S, 8″S)-4′,5″-dihydroxy-3,5,3′,4″-tetramethoxy-7,9′:7′,9-diepoxy-4,8″-oxy-8,8′-sesquineo-lignan-7″,9″-diol (boldFont">1), (7R, 7'R, 7″S, 8S, 8′S, 8″S)-4′,3″-dihydroxy-3,5,3′,5′,4″-pentamethoxy-7,9′:7′,9-diepoxy-4,8″-oxy-8,8′-sesquineo-lignan-7″,9″-diol (boldFont">2), (7R, 7'R, 7″S, 8S, 8′S, 8″S)-3′,4″-dihydroxy-3,5,4′,5″-tetramethoxy-7,9′:7′,9-diepoxy-4,8″-oxy-8,8′-sesquineo-lignan-7″,9″-diol (boldFont">3) and acanthopanax A (boldFont">7) together with three known compounds (boldFont">4–boldFont">6) were isolated from the EtOAc-soluble extract of Acanthopanax senticosus. Their structures were elucidated on the basis of spectroscopic and physicochemical analyses. All the isolates were evaluated for in vitro inhibitory activity against DGAT1 and DGAT2. Among them, compounds boldFont">1–boldFont">6 were found to exhibit selective inhibitory activity on DGAT1 with IC₅₀ values ranging from 61.1 ± 1.3 to 97.7 ± 1.1 μM and compound boldFont">7 showed selective inhibition of DGAT2 with IC₅₀ value 93.2 ± 1.2.