Estrogenic and anti-estrogenic influences in cultured brown trout hepatocytes: Focus on the expression of some estrogen and peroxisomal related genes and linked phenotypic anchors
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- 作者：Tâ ; nia Vieira Madureiraa ; b ; tvmadureira@icbas.up.pt" class="auth_mail" title="E-mail the corresponding author ; Fernanda Malhã ; oa ; b ; Ivone Pinheiroa ; b ; Cé ; lia Lopesa ; b ; Ná ; dia Ferreiraa ; b ; Ralph Urbatzkaa ; L. Filipe C. Castroa ; c ; Eduardo Rochaa ; b
- 关键词：Ethinylestradiol ; ICI 182 ; 780 ; Peroxisomes ; Hepatocytes ; Brown trout
- 刊名：Aquatic Toxicology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：169
- 期：Complete
- 页码：133-142
- 全文大小：1905 K
文摘
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Evidence of crosstalk between estrogens and peroxisomal pathways in brown trout.
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VtgA and ERα mRNA levels increased after 1, 10 and 50 μM of ethinylestradiol (EE2).
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ERβ-1, catalase and urate oxidase mRNA levels decreased after estrogenic stimuli.
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Estrogenic effects in VtgA, ERα and Uox mRNA levels were reverted by ICI 182,780.
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Immunofluorescence/electron microscopy shows smaller peroxisomes after 50 μM of EE2.