Association study between sick building syndrome and polymorphisms of seven human detoxification genes in the Japanese

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• 作者：Yasunari Matsuzaka ; Yukie Y. Kikuti ; Akiko Mizutani ; Yoshiko Aoyama ; Kazuhiko Kakuta ; Akira Oka ; Hidetoshi Inoko ; Kou Sakabe ; Satoshi Ishikawa ; Jerzy K. Kulski ; Minoru Kimura
• 关键词：Sick building syndrome ; Detoxification genes ; SNPs ; Association study
• 刊名：Environmental Toxicology and Pharmacology
• 出版年：2010
• 出版时间：March 2010
• 年：2010
• 卷：29
• 期：2
• 页码：190-194
• 全文大小：200 K

文摘

Sick building syndrome (SBS) is a chronic disorder caused by exposure to diverse indoor environmental or chemical pollutants. This study examined the association between seven detoxification genes (CYP1A1, CYP2E1, EPHX1, GSTM1, GSTT1, GSTP1, and NAT2) and SBS in the Japanese population. One hundred eighty patients with SBS and 401 healthy controls were enrolled in this study. We examined the prevalence for total of eleven genetic polymorphisms of detoxification genes. However, no statistically significant differences in allele and genotype frequency distributions of eleven genetic polymorphisms of these detoxification genes were found between patients and controls. On this basis, we conclude that the polymorphisms that we assessed for the detoxification genes do not contribute to the etiology of SBS.