S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents
文摘
3,5-Dinitrophenyl tetrazoles and oxadiazoles with high antimycobacterial activity. MIC values of 0.03–0.06 μM against Mycobacterium tuberculosis. Activity against MDR/XDR strains and no cross-resistance with common anti-TB drugs. Selective antitubercular effect and low in vitro toxicity to mammalian cell lines. Defined structure-activity relationships.