In vitro and in vivo anti-inflammatory effects of 4-methoxy-5- hydroxycanthin-6-one, a natural alkaloid from Picrasma quassioides

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• 作者：Huaying Fan^a ; Dong Qi^b ; Mingyan Yang^c ; Hui Fang^a ; Ke Liu^a ; ^c ; Feng Zhao^a ; ^{zhaofeng74@yahoo.com.cn}
• 关键词：CAN ; 4-methoxy-5-hydroxycanthin-6-one ; FBS ; fetal bovine serum ; LPS ; lipopolysaccharide ; NO ; nitric oxide ; TNF-¦Á ; tumor necrosis factor-¦Á ; IL-1¦Â ; interleukin 1¦Â ; AA ; adjuvant-induced arthritis
• 刊名：Phytomedicine
• 出版年：2013
• 出版时间：15 February, 2013
• 年：2013
• 卷：20
• 期：3-4
• 页码：319-323
• 全文大小：589 K

文摘

In the present study, we evaluated the anti-inflammatory effect of 4-methoxy-5- hydroxycanthin-6-one (CAN), a natural alkaloid isolated from Picrasma quassioides. CAN significantly inhibited the production of NO and the release of TNF-¦Á induced by LPS in macrophage RAW 264.7. Western blot showed that CAN can downregulate the expression of iNOS protein. After oral administration, CAN (3, 9, and 27 mg/kg) reduced the development of carrageenan-induced paw edema and complete Freund's adjuvant (CFA)-induced chronic arthritis in rats. The observed results indicated that pre-treatment with CAN might be an effective therapeutic intervention against inflammatory diseases including chronic arthritis.