A glutamate uptake blocker occludes Aβ-mediated inhibition of E–S potentiation.
Impairment of E–S potentiation by Aβ oligomers involves changes in GABAergic tone.
Aβ oligomers increase both population spike frequency and spontaneous EPSC frequency.
Decreasing neuronal activity prevents Aβ oligomer-impaired hippocampal LTP.
Anticonvulsants restore Aβ oligomer-impaired hippocampal LTP.