| Figure
s/Table
sFigure
s/Table
s | Reference
sReference
ssion=""1.0"" encoding=""UTF-8""?>
ss=""h3"">Summary
The Ta
smanian devil (
Sarcophilus harrisii), the large
st mar
supial carnivore, i
s endangered due to a tran
smi
ssible facial cancer
spread by direct tran
sfer of living cancer cell
s through biting. Here we de
scribe the
sequencing, a
ssembly, and annotation of the Ta
smanian devil genome and whole-genome
sequence
s for two geographically di
stant
subclone
s of the cancer. Genomic analy
si
s sugge
st
s that the cancer fir
st aro
se from a female Ta
smanian devil and that the clone ha
s sub
sequently genetically diverged during it
s spread acro
ss Ta
smania. The devil cancer genome contain
s more than 17,000
somatic ba
se
sub
stitution mutation
s and bear
s the imprint of a di
stinct mutational proce
ss. Genotyping of
somatic mutation
s in 104 geographically and temporally di
stributed Ta
smanian devil tumor
s reveal
s the pattern of evolution and
spread of thi
s para
sitic clonal lineage, with evidence of a
selective
sweep in one geographical area and per
si
stence of parallel lineage
s in other population
s.
ss=""h4"">PaperClip
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