Theoretical calculations, DNA interaction, topoisomerase I and phosphatidylinositol-3-kinase studies of water soluble mixed-ligand nickel(II) complexes
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- 作者：Perumal Gurumoorthy ; Dharmasivam Mahendiran ; Aziz Kalilur Rahiman ; akrahmanjkr@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Water soluble complexes ; Theoretical calculations ; Calf thymus DNA ; Topoisomerase I inhibitors ; PI3K receptor ; DNA cleavage activity
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：25 March 2016
- 年：2016
- 卷：248
- 期：Complete
- 页码：21-35
- 全文大小：2543 K
文摘
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The water soluble complexes possess notable scavenging potency against DPPH radical.
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Complexes exhibit groove/electrostatic binding to DNA, and cleave DNA efficiently.
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Topoisomerase I inhibition activity have been studied.
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Complexes show hydrogen bonding, hydrophobic and σ–π interactions with PI3K.
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Complexes containing methyl/extended aromatic ring show significant bio-activity.