According to 96 h-LC50 values, the order of toxicity was as follows: CPM > PRO > MAL.
Binary mixture of MAL + CPM displayed a synergistic effect on the acute toxicity to zebrafish larvae, and MAL + PRO showed an antagonistic effect.
Transcription of many key genes involved in the HPG axis was a significantly altered after exposure to MAL + CPM and MAL + PRO.