Glucose metabolism-weighted imaging with chemical exchange-sensitive MRI of 2-deoxyglucose (2DG) in brain: Sensitivity and biological sources

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• 作者：Tao Jin^a ; ^b ; ^{taj6@pitt.edu} ; Hunter Mehrens^a ; Ping Wang^a ; Seong-Gi Kim^c ; ^d
• 关键词：CMRglu ; Glucose transport ; Glucose metabolism ; PET ; MRI ; CEST ; CESL
• 刊名：NeuroImage
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：143
• 期：Complete
• 页码：82-90
• 全文大小：2371 K
• 卷排序：143

文摘

Chemical exchange-sensitive spin-lock (CESL) MRI signal increases linearly with 2DG dose at initially but not at later periods. The 2DG-CESL signal is reduced at higher isoflurane anesthesia levels correlating well with glucose metabolism rate. 2DG-CESL signal shows spatial heterogeneity and is higher in gray matter than white matter. 2DG-CESL predominantly measures chemical exchange-related signals in the extravascular space.