Human Brain Evolution: Harnessing the Genomics (R)evolution to Link Genes, Cognition, and Behavior

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• 作者：Genevieve Konopka ; Daniel H. Geschwind
• 刊名：Neuron
• 出版年：2010
• 出版时间：21 October 2010
• 年：2010
• 卷：68
• 期：2
• 页码：231-244
• 全文大小：786 K

文摘

The evolution of the human brain has resulted in numerous specialized features including higher cognitive processes such as language. Knowledge of whole-genome sequence and structural variation via high-throughput sequencing technology provides an unprecedented opportunity to view human evolution at high resolution. However, phenotype discovery is a critical component of these endeavors and the use of nontraditional model organisms will also be critical for piecing together a complete picture. Ultimately, the union of developmental studies of the brain with studies of unique phenotypes in a myriad of species will result in a more thorough model of the groundwork the human brain was built upon. Furthermore, these integrative approaches should provide important insights into human diseases.