Targeted therapeutic delivery using engineered exosomes and its applications in cardiovascular diseases
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- 作者：Dang Xitong ; xitongdang1024@163.com" class="auth_mail" title="E-mail the corresponding author ; Zeng Xiaorong
- 关键词：miRNA ; microRNA ; siRNA ; small interference RNA ; lncRNA ; long non-coding RNA ; ILVs ; intraluminal vesicles ; MVBs ; multivesicular bodies ; CD ; cluster of differentiation ; HSP ; heat shock protein ; SDCBP ; syndecan binding protein ; EBV ; Epstein&ndash ; Barr virus ; RVG ; rabies virus glycoprotein ; iRGD ; internalizing arginine&ndash ; glycine&ndash ; aspartic acid peptide ; ORF ; open reading frame ; PCR ; polymerase chain reaction ; EGF ; epidermal growth factor ; PC ; prostate cancer ; LAMP-2b ; lysosome-associated mem
- 刊名：Gene
- 出版年：2016
- 出版时间：10 January 2016
- 年：2016
- 卷：575
- 期：2
- 页码：377-384
- 全文大小：528 K
文摘
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Exosomes are natural carriers of signaling molecules including miRNA.
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Membrane proteins including tetraspanins are selectively enriched on membrane of exosomes.
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Homing peptides targeting unknown receptors in vivo can be displayed on the surface of exosomes.
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Surface display of homing peptides can be easily achieved by fusion with tetraspanins using overlapping PCR.
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Engineered exosomes can be loaded with therapeutic miRNAs to realize targeted delivery in vivo.