Insulin-like growth factor-II mRNA binding protein-3 and podoplanin expression are associated with bone invasion and prognosis in oral squamous cell carcinoma
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- 作者：Young Sun Hwanga ; 1 ; Sung Yong Ahnb ; e ; 1 ; Sook Moonb ; Zhenlong Zhengc ; In-Ho Chae ; Jin Kimb ; e ; Xianglan Zhangd ; e ; zhangxianglan@yuhs.ac" class="auth_mail" title="E-mail the corresponding author
- 关键词：IMP3 ; PDPN ; Bone invasion ; Oral squamous cell carcinoma
- 刊名：Archives of Oral Biology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：69
- 期：Complete
- 页码：25-32
- 全文大小：1678 K
文摘
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The prognostic implications of the IMP3-PDPN axis as therapeutic targets against OSCC with bone invasion are proposed.
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Dual expression of IMP3 and PDPN but not the single expression of either IMP3 or PDPN was associated with bone invasion in patients with OSCC.
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IMP3 or PDPN depletion inhibited the invasive capacity of OSCC cells in vitro, tumorigenesis and regional bone destruction in vivo.
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IMP3 and PDPN may have strong influence on OSCC pathogenesis, especially in bone invasion of OSCC.