Neuroprotection of agomelatine against cerebral ischemia/reperfusion injury through an antiapoptotic pathway in rat

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• 作者：Wijitra Chumboatong^a ; Sarinthorn Thummayot^b ; Piyarat Govitrapong^c ; ^d ; Chainarong Tocharus^b ; Jinatta Jittiwat^e ; Jiraporn Tocharus^a ; ^{jtocharus@gmail.com}
• 关键词：Cerebral ischemia/reperfusion ; Agomelatine ; Apoptosis ; Antioxidant ; Melatonin ; Nrf2
• 刊名：Neurochemistry International
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：102
• 期：Complete
• 页码：114-122
• 全文大小：3164 K
• 卷排序：102

文摘

Agomelatine protects brain from cerebral I/R injury by suppressing apoptosis. Agomelatine may be a potential candidate for treating ischemic stroke Agomelatine protects brain damage mediated by oxidative stress pathway.