Stereoselective synthesis of trans-perfluoroalkylated [1,3]oxazino[2,3-a]isoquinolines from aromatic aldehydes, methyl perfluoroalk-2-ynoates and isoquinolines
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- 作者：Zhiliang Xua ; 1 ; Tianqi Suna ; 1 ; Qiuqi Caia ; Fei Nia ; Jing Hana ; Jie Chena ; Hongmei Dengd ; Min Shaod ; Hui Zhangd ; yehao7171@shu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Weiguo Caoa ; b ; c ; wgcao@staff.shu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Multi-component reaction ; Perfluoroalkyl-substituted isoquinoline ; Fused 1 ; 3-oxazine ; Regioselectivity ; Diastereoselectivity
- 刊名：Journal of Fluorine Chemistry
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：181
- 期：Complete
- 页码：45-50
- 全文大小：605 K
文摘
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An easy metal-free access to trans-perfluoroalkylated [1,3]oxazino[2,3-a]isoquinolines.
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1,4-Dipolar cycloadditions to provide six-membered heterocyclic compounds.
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Isoquinoline as the nucleophilic reagent.
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Regioselectivity and diastereoselectivity of the cycloaddition.