Placental vascularity and markers of angiogenesis in relation to prenatal growth status in overnourished adolescent ewes
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- 作者：David J. Carra ; b ; davidcarr@doctors.org.uk" class="auth_mail" title="E-mail the corresponding author ; Anna L. Davidb ; Raymond P. Aitkena ; John S. Milnea ; Pawel P. Borowiczc ; Jacqueline M. Wallacea ; Dale A. Redmerc
- 关键词：Placental vascularity ; Fetal growth restriction ; Angiogenic factors ; Sheep ; Angiopoietin
- 刊名：Placenta
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：46
- 期：Complete
- 页码：79-86
- 全文大小：1327 K
文摘
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Overnourishment of adolescent sheep dams produces FGR in approximately 50% of cases.
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Cotyledonary vascularity is increased in overnourished vs. control-intake pregnancy.
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Cotyledonary vascularity is highest in non-FGR cases, suggesting greater adaptation.
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Changes in cotyledonary vascularity are mirrored by angiopoietin-2 mRNA expression.
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Caruncular angiogenic ligands are reduced in FGR without any changes in vascularity.