Gremlin1 induces anterior-posterior limb bifurcations in developing Xenopus limbs but does not enhance limb regeneration
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- 作者：Yi-Hsuan Wanga ; 1 ; Samuel R. Keenana ; 1 ; Jeremy Lynna ; James C. McEwana ; Caroline W. Becka ; b ; caroline.beck@otago.ac.nz" class="auth_mail" title="E-mail the corresponding author
- 关键词：Xenopus ; Grem1 ; Limb bud ; Digit identity ; Branching morphogenesis ; Regeneration ; Polydactyly ; Ectopic limbs
- 刊名：Mechanisms of Development
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：138
- 期：part_P3
- 页码：256-267
- 全文大小：2100 K
文摘
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Grem1 is upregulated during limb bud regeneration in Xenopus.
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Ectopic grem1 does not prevent regeneration but affects the re-development phase.
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Ectopic grem1 causes developing limbs to bifurcate along the proximodistal axis.
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Grem1 induced limb duplications have normal symmetry.
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The anteroposterior pattern of the original limb bud is inverted, and shh expanded.