Enhanced expression of the calcium-sensing receptor in reactive astrocytes following ischemic injury in vivo and in vitro
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- 作者：Ha-Jin Pak ; Tae-Ryong Riew ; Yoo-Jin Shin ; Jeong-Heon Choi ; Xuyan Jin ; Mun-Yong Lee ; munylee@catholic.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：CaSR ; calcium-sensing receptor ; OGD ; oxygen&ndash ; glucose deprivation ; GFAP ; glial fibrillary acidic protein
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：366
- 期：Complete
- 页码：102-109
- 全文大小：2849 K
文摘
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We show temporal regulation of CaSR expression in the ischemic hippocampus.
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The CA1 region showed long-lasting CaSR expression in reactive astrocytes.
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CaSR induction was astrocyte-specific and absent from microglia and macrophages.
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CaSR expression was upregulated in cultured astrocytes exposed to OGD.