Neonatal hypoxic ischemic encephalopathy-related biomarkers in serum and cerebrospinal fluid
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- 作者：Hongyan Lva ; b ; Qiuli Wanga ; Sujing Wua ; b ; Lihong Yanga ; Pengshun Rena ; Yihui Yangc ; Jinsheng Gaod ; Lianxiang Lib ; c ; lianxianglm68@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：HIE ; Neonatal hypoxic ischemic encephalopathy ; MIR ; magnetic resonance imaging ; CSF ; Cerebrospinal fluid ; ATP ; Adenosine triphosphate ; NSE ; Neuron specific enolase ; MBP ; Myelin basic protein ; FAP ; Glial fibrillary acidic protein ; UCH-L1 ; Ubiquitin carboxyl-terminal hydrolase ; BDNF ; Brain-derived neurotrophic factor ; miRNA ; MicroRNA ; MMP-9 ; Matrix metalloproteinase-9 ; ICAM-1 ; intercellular adhesion molecular-1 ; sLCAM-1 ; Soluble intercellular adhesion molecule 1 ; VEGF ; Vascular endothelial growth
- 刊名：Clinica Chimica Acta
- 出版年：2015
- 出版时间：23 October 2015
- 年：2015
- 卷：450
- 期：Complete
- 页码：282-297
- 全文大小：449 K
文摘
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Biomarker application in neonatal hypoxic ischemic encephalopathy is introduced.
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S-100尾 and activin A are good markers for early diagnosis of neonatal HIE.
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GFAP and UCH-L1 are promising biomarkers to predict the long-term neurologic handicap.
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Optimized combination of biomarkers is proposed to enhance neonatal HIE diagnosis.