Efficient one-pot syntheses of 2H-indazolo[2,1-b] phthalazine-triones by catalytic H₂SO₄ in water–ethanol or ionic liquid

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• 作者：Jitender M. Khurana ; Devanshi Magoo
• 关键词：Dimedone ; Cyclohexane-1 ; 3-dione ; Phthalhydrazide ; H₂SO₄ ; Ionic liquid ; Water– ; ethanol ; Indazolophthalazine
• 刊名：Tetrahedron Letters
• 出版年：2009
• 出版时间：30 December 2009
• 年：2009
• 卷：50
• 期：52
• 页码：7300-7303
• 全文大小：183 K

文摘

Sulfuric acid-catalyzed, three-component, one-pot condensation of phthalhydrazide, aromatic aldehydes and 1,3-dicarbonyl compounds has been reported for the synthesis of a series of 2H-indazolo[2,1-b] phthalazine-triones in water–ethanol or in ionic liquid. The protocol proves to be efficient and environmentally benign in terms of high yields, low reaction times, ease of recovery, and reusability of reaction medium (ionic liquid).