Assessing the safety of cosmetic chemicals: Consideration of a flux decision tree to predict dermally delivered systemic dose for comparison with oral TTC (Threshold of Toxicological Concern)
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- 作者：Faith M. Williamsa ; publications@ilsieurope.be" class="auth_mail" title="E-mail the corresponding author ; Helga Rotheb ; Gordon Barrettc ; Alessandro Chiodinid ; Jacqueline Whyted ; Mark T.D. Cronine ; Nancy A. Monteiro-Rivieref ; James Plautzg ; Clive Roperh ; Joost Westerhouti ; Chihae Yangj ; Richard H. Guyk
- 关键词：Threshold of Toxicological Concern (TTC) ; Dermal ; Cosmetic chemical ; Systemic bioavailability ; Decision tree ; Prediction ; Flux
- 刊名：Regulatory Toxicology and Pharmacology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：76
- 期：Complete
- 页码：174-186
- 全文大小：1639 K
文摘
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Construction of decision tree to predict dermal absorption of cosmetic chemicals based on skin exposure scenarios.
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Used a predictive algorithm based on Potts and Guy equation for maximum flux adjusted to actual dose.
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Ranked systemic availability against oral TTC.
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Case studies with experimental data indicated reliability of predictions.