2-(Phenylsulfonyl)quinoline N-hydroxyacrylamides as potent anticancer agents inhibiting histone deacetylase
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- 作者：Hsueh-Yun Leea ; Chih-Yi Changa ; Chih-Jou Sub ; Han-Li Huangb ; Samir Mehndirattaa ; Yuh-Hsuan Chaoa ; Chia-Ming Hsub ; Sunil Kumara ; Ting-Yi Sungb ; Yi-Zhen Huangb ; Yu-Hsuan Lia ; Chia-Ron Yangc ; cryang@ntu.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Jing-Ping Lioua ; jpl@tmu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Anticancer agents ; Histone deacetylase inhibitors ; 2-(Phenylsulfonyl)quinoline
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：21 October 2016
- 年：2016
- 卷：122
- 期：Complete
- 页码：92-101
- 全文大小：928 K
文摘
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A series of 2-(phenylsulfonyl)quinoline N-hydroxyacrylamides were designed and synthesized.
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Two compounds (8f and 8j) with potent antiproliferative activity were identified.
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Compounds 8f was potent to inhibit HDAC function.